Fights COVID Like Hydroxychloroquine, yet Easier to Find

https://www.theepochtimes.com/fights-covid-like-hydroxychloroquine-yet-easier-to-find_4179040.html

“Fights COVID Like Hydroxychloroquine, yet Easier to Find”

One COVID-19-specific study found that people who took zinc and two zinc ionophores — quinine drops and quercetin — had lower incidence of COVID-19 than the control group.

Over the course of the study (20 weeks), only two of the 53 test subjects became symptomatic, compared to 12 of the 60 controls.

https://moderndiscontent.substack.com/p/quercetin-an-over-the-counter-hydroxychloroquine-d09

It’s important to note that this study used many compounds including

zinc

drops of Quina (Quinine)

Quercetin

vitamin C, D3, E

l-Lysine

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The control group seems to have been given everything besides Zinc or the ionophores (quinine and Quercetin).

In that sense, the difference between the two groups would be dependent upon the administration of Zinc and ionophores.

20-Week Study of Clinical Outcomes of Over-the-Counter COVID-19 Prophylaxis and Treatment

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264737/

Administration Methods and Dosages

We followed subjects’ oral administration, via self-administration and/or as supervised by caregiver, of components of the formulations, including via drops and powders (as mixed in liquids such as water or juice), capsules and tablets. The majority of administration compliance reporting was self-reported by subjects.

Oral administration was the sole method of administration assessed in this study.

For disease prophylaxis

One dose daily of the full core formulation regimen, containing:

• 25 mg zinc;
• 10 drops of Quina^™ (on average; the quina-bark extract may be titrated, as tolerated by some subjects, starting at 1 drop then building up to 8-16 drops daily, but which latter may be taken as two 4-8 drop half-doses twice daily);
• 400 mg quercetin;
• 1000 mg vitamin C;
• 1000 IU (25 μg) vitamin D3;
• 400 IU Vitamin E; and
• 500 mg l-lysine.

Other amounts and proportions of these substances and components per dose may have, in practical application, been used by some test subjects. Such individualized dosing, while noted when possible, was not statistically assessed separately from the recommended dosing. Also not assessed was use of additional/ancillary components and methods presented above, such as 1 mg daily of copper bisglycinate to be taken several hours after/before the regimen dose.

Prevention-dosing, administered throughout the study period, is being maintained as ongoing prophylaxis by many subjects who report following our suggestion to continue with it over any period of acute concern of contracting COVID-19 or other viral diseases.

For early-stage disease amelioration/alleviation

Multiples daily of the prevention-dose were administered. The multiple dose followed in the study was 2; i.e., for study test group subjects presenting symptoms of flu-like illness, we followed use of 2 prevention doses per day, administered separately or together. On the second day of administration in those mild to moderate flu-like cases, we initiated incremental increase of the zinc over 2-3 days to as high as 200 mg/day, as tolerated. (Those telemedicine patients, not part of the study, who called in describing likely COVID-19 symptoms, were advised to take treatment-dosing levels of the formulations.)

At least for addressing co/secondary bacterial infection, patient and/or caregiver may consider adding, as prescribed by a treating physician, 500 mg daily azithromycin for 5 days, or even a course of 100 mg twice daily of doxycycline for 7 days. In all cases of active clinical COVID-19 in this study, other than 1 course of doxycycline for 1 subject, no antibiotics were prescribed by primary care providers or other treating practitioners.

Treatment dosing was administered for 1-5 days or until symptoms were ameliorated/alleviated. Following symptom amelioration/alleviation, prevention-dosing was resumed.

20-Week Study of Clinical Outcomes of Over-the-Counter …https://journals.sagepub.com › doi › fullby L Margolin · 2021 · Cited by 4 — Zinc ionophore activity has been shown in the alkaloid quinine and its chloroquine derivatives. For the study quinine-based zinc ionophore …
20-Week Study of Clinical Outcomes of Over-the … – NCBIhttps://www.ncbi.nlm.nih.gov › articles › PMC8264737by L Margolin · 2021 · Cited by 4 — This includes modalities that can readily be used by the public to reduce disease spread and severity. Such preventive measures and early-stage …
20-Week Study of Clinical Outcomes of Over-the-Counter …https://groups.wenxuecity.com › groups › bbsSep 29, 2021 — In implementation over the study period, most test group subjects reported consistent use of the recommended doses of zinc and vitamins C and E; …
Over-the-Counter COVID-19 Prophylaxis and Treatment – CFS …https://www.cfs-resource.net › health-wellbeing › over-t…We present results of a clinical study with a multi-component OTC “core formulation” regimen used in a multiply exposed adult population. Analysis of clinical …

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264737/

Role of zinc ionophores

Zinc ionophores can increase importation of zinc into cells. Increasing intracellular Zn⁺² concentration via zinc ionophores can efficiently impair intracellular replication of a variety of RNA viruses, including poliovirus, influenza virus and COVID-19-causing SARS-CoV-2 coronavirus, as demonstrated with such zinc ionophores as pyrrolidine dithiocarbamate and pyrithione. ²³

Zinc ionophores can thus be utilized to gain the anti-viral benefit of enhanced intracellular Zn⁺² concentrations while limiting tolerance/side-effect/toxicity issues ^24–26 associated with elevated serum levels of zinc supplementation. Another consideration for judicious selection of study zinc ionophore candidates included the compounds conferring additional benefits, particularly immunity health benefits.

Quina bark derivatives as zinc ionophores

Zinc ionophore activity has been shown in the alkaloid quinine ²⁷ and its chloroquine derivatives. ²⁸ For the study quinine-based zinc ionophore sourcing, we used Quina™ (NutraMedix; Jupiter, Florida USA), produced by a “proprietary [water: ethanol] extraction and enhancement process” from the bark of the quina plant Cinchona calisaya. There is no reason to believe that similar quina-bark-based extracts or derivatives would not serve as appropriate sourcing. We expect that extracts, tinctures or other preparations of quinine-containing plants, including but not limited to Quina Roja, can be adopted.

Quinine has also been shown to have an independent anti-viral activity against the COVID-19-causing SARS-CoV-2 coronavirus. ²⁹ Additionally, there is evidence of an anti-TNFα effect of quinine ³⁰ that may be contributory to the assumed protective anti-inflammatory effect for COVID-19 patients. For example, research on IBD patients relative to SARS-CoV-2 shows possible protective effects of anti-TNFα antibodies in Crohn’s patients. ³¹

Quercetin as zinc ionophore

Quercetin, a bioflavonoid polyphenol, has been shown to act as a zinc ionophore, ³² enhancing entrance of zinc into cells to inhibit viral intracellular replication. It is also believed to block viruses from entering cells in the first place. An Oak Ridge National Labs/University of Tennessee study of many FDA-approved compounds presented supercomputer modeling results for inhibition by them of SARS-CoV-2 viral S-spike binding to cells. The study ranked quercetin as fifth out of 20 top performers. ³³

Studies have shown quercetin also exhibiting anti-inflammatory properties, ^{34 –36} which could help mitigate the inflammatory response of cytokine and/or bradykinin storms provoked by COVID-19. A wide range of anti-viral/immunity benefits of quercetin have been identified, ^{37 –41} as well as other health benefits that may address some comorbidities of COVID-19 ^{42 –44} and some of its sequelae. ^44,45

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http://www.kathydopp.info/COVIDinfo/COVIDTreatments

20-Week Study of Clinical Outcomes of Over-the-Counter COVID-19 Prophylaxis and Treatment. Leon Margolin, MD, PhD, Jeremy Luchins, PhD, Daniel Margolin, Bsc, …July 6, 2021. a 20-week study of our clinical experience with a multi-component over-the-counter (OTC) “core formulation” regimen used in a multiply exposed, high risk population. The OTC core supplementation formulations used include zinc and zinc ionophores (quinine-based quina plant bark extract and quercetin); vitamins C, D3 and E; and l-lysine.  These observations demonstrate the efficacy of supplementation with zinc (25 mg daily) and zinc ionophores, and at least some of the other core formulation components, as prophylaxis against COVID-19 and other flu-like illnesses; and demonstrate the relative lack of anti-flu/anti-COVID-19 prophylactic efficacy of supplementation with vitamin C or D3 in the absence of zinc and zinc ionophores.

One dose daily of the full core formulation regimen, containing:

• 25 mg zinc;
• 10 drops of Quina™ (on average; the quina-bark extract may be titrated, as tolerated by some subjects, starting at 1 drop then building up to 8-16 drops daily, but which latter may be taken as two 4-8 drop half-doses twice daily);
• 400 mg quercetin;
• 1000 mg vitamin C;
• 1000 IU (25 μg) vitamin D3;
• 400 IU Vitamin E; and
• 500 mg l-lysine.

Review of Formulations and Methods for Prevention and Treatment of COVID-19 and other Viral Infections

Leon Margolin*, Jeremy Luchins, Daniel Margolin, Michelle Margolin, Sanford Lefkowitz

https://www.gavinpublishers.com/article/view/review-of-formulations-and-methods-for-prevention-and-treatment-of-covid-19-and-other-viral-infections

Methods specification, route of administration

Oral administration, when possible, of the formulations via capsule, powder, soft gel, tablet, mixture in such liquids as water or juice, or other forms of administration.

Formulation ingredients may be divided among various modes of administration, such as: IV or other parenteral routes for vitamins C and E, extracts containing quinine-analogs/derivatives, and/or zinc; and PEG administration for vitamin D3, L-Lysine, and/or other components and substances of the formulations.

For treatment of moderate to severe disease, administration of two doses per day, each dose containing:

400 mg of Quercetin together 10 drops of Quina (we used NutraMedix Cinchona Calisaya extract to good effect. However, all similar plant extracts including, but not limited to Quina Raja, Cinchona extracts, Quinine tinctures, extracts or other preparations, teas or powders may be used) with 25 mg of Zn, 1000 mg of Vitamin C, 400 IU of Vitamin E, 500 mg of L- Lysine, and 1000 units of Vitamin D3.

Other amounts and proportions of these substances and components may be used.

After the first day of administration of the formulations, we recommend, in addition to the two doses/day indicated above, also another 50 mg of Zn the second day, titrated up to 200 mg of Zn over 2-3 days for 5 days as tolerated.

We anticipate and advocate use of none, one or more than one of the additional/ancillary substances and components (For instance, if copper orotate is used, we recommend 1 mg/dose). Patient condition may indicate yet additional/ancillary treatment components. For instance, for patients with pulmonary symptoms with contraindications and drug interactions, we anticipate and advocate as useful Bupleurum extract, with possible dosing of 1 gm daily (via tablet, tincture or other means or preparations/administration).

We anticipate and advocate considering supplementing the above regimen with one or more antibiotics and/or anti-parasitic agents (each by prescription by the treating physician), for instance: Azithromycin (Zithromax) 500 mg daily for 5 days; Ivermectin [17], with possible dosing being 3 mg, typically orally or by PEG, if possible titrating to up 15 mg (or as indicated and as tolerated) for a single dose, with a single dose repeat in 7 days (or as indicated and as tolerated); Isoniazide, Nitrofurantoin, Doxycycline and/or Levaquin (for secondary infection prevention) or other medications (dosing per PDR).

We note that the formulations without prescription-necessary supplementation (i.e., entirely OTC), have been demonstrated effective in preventing COVID-19 at 1 dose/day; and, at 2 doses/day with no or only minimal prescription-necessary supplementation (e.g., only Azithromycin, Doxycycline or other medications, as above), are considered effective in treating the mild to moderate symptoms of early-stage COVID-19. Thus, prophylactic use of our OTC formulations and early use of the OTC formulations plus minimal antibiotic supplementation may significantly reduce the incidence of the moderate to severe symptoms of later-stage COVID-19 that may require expensive, scarce or potentially risk-bearing prescribed medications and/or in-hospital procedures. As noted, use of our OTC formulations and methods may prevent virus spread from asymptomatic carriers and, thus, help address threats of “second wave infections.”

In addition, our formulations and methods may have beneficial effects on weight reduction, blood pressure control [20], diabetes [21], cardiovascular health [22], mood and memory [23].

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“zinc” “quercetin” “quinine” “quina” “C” “D3” “E” “L-lysine” “extracts containing quinine-analogs/derivatives”

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Review of Formulations and Methods for Prevention and …https://www.gavinpublishers.com › article › view › revi…Quina is the source for the malaria treatment quinine, of which the highest … C, 400 IU of Vitamin E, 500 mg of L-Lysine, and 1000 units of Vitamin D3.

• 
  Journal of Diabetes and Treatment – Gavin Publishershttps://www.gavinpublishers.com › articles_pdfPDF

by L Margolin · 2020 — vitamins C and E, extracts containing quinine-analogs/derivatives, and/or zinc; and PEG administration for vitamin D3, L-Lysine,.

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Journal of Diabetes and Treatment – Comprehensive Pain …https://cpmiohio.com › JDBT-179.x18791.pdfPDFby L Margolin · 2020 — A mixture of Quercetin together with drops of Quina … vitamins C and E, extracts containing quinine-analogs/derivatives, and/or zinc …
(PDF) Journal of Diabetes and Treatment Review Article …https://www.researchgate.net › publication › 346010288_…Jul 8, 2021 — A mixture of Quercetin together with drops of Quina … vitamins C and E, extracts containing quinine-analogs/derivatives,. and/or zinc; and …

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Comprehensive Pain Management Institute, LLC
Columbus, Ohio, USA
Leon Margolin

MERCOLA, MARGOLIN

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